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  {
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  {
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  {
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  {
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  {
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  {
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  {
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      {
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  {
    "family_id": "RAPID-axSpA",
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  {
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      "lower": -0.19,
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  {
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  {
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      {
        "url": "https://www.ebi.ac.uk/europepmc/webservices/rest/PMC6477523/supplementaryFiles",
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  },
  {
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        "access": "companion supplement not inspected"
      }
    ],
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    "registry_history": "Not verified"
  },
  {
    "family_id": "ENRADAS",
    "family_doi": "10.1186/s13075-019-1911-1",
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    "arm": "Continuous/on-demand NSAID pooled",
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    "threshold": "mSASSS change <=0",
    "construct": "composite spinal mSASSS nonprogression",
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    "uncertainty": null,
    "uncertainty_reason": "not reported for this rate in inspected table/text",
    "denominator_n": 69,
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    "missing_data": "paired available films; no imputation described",
    "source_location": "Companion DOI10.1186/s13075-019-1911-1 Table2 primary set",
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    "supplementary_access": [
      {
        "url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC6555995/#MOESM1",
        "access": "not inspected"
      }
    ],
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    "registry_history": "Not verified"
  },
  {
    "family_id": "ENRADAS",
    "family_doi": "10.1186/s13075-019-1911-1",
    "url": "https://doi.org/10.1186/s13075-019-1911-1",
    "endpoint_id": "ENRADAS_le05",
    "arm": "Continuous/on-demand NSAID pooled",
    "population": "ENRADAS historical Primary Analysis Set",
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    "threshold": "mSASSS change <=0.5",
    "construct": "composite spinal mSASSS nonprogression",
    "rate_percent": 62.3,
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    "uncertainty_reason": "not reported for this rate in inspected table/text",
    "denominator_n": 69,
    "estimate_type": "reported table percentage; logistic regression used for cohort comparison",
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    "supplementary_access": [
      {
        "url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC6555995/#MOESM1",
        "access": "not inspected"
      }
    ],
    "review_scope": "Pivotal numerical inputs internally cross-checked; not every field independently re-extracted. No external review.",
    "registry_history": "Not verified"
  },
  {
    "family_id": "ENRADAS",
    "family_doi": "10.1186/s13075-019-1911-1",
    "url": "https://doi.org/10.1186/s13075-019-1911-1",
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    "arm": "Continuous/on-demand NSAID pooled",
    "population": "ENRADAS historical Primary Analysis Set",
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    "threshold": "mSASSS change <=1",
    "construct": "composite spinal mSASSS nonprogression",
    "rate_percent": 69.6,
    "uncertainty": null,
    "uncertainty_reason": "not reported for this rate in inspected table/text",
    "denominator_n": 69,
    "estimate_type": "reported table percentage; logistic regression used for cohort comparison",
    "missing_data": "paired available films; no imputation described",
    "source_location": "Companion DOI10.1186/s13075-019-1911-1 Table2 primary set",
    "source_doi": "10.1186/s13075-019-1911-1",
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    "supplementary_access": [
      {
        "url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC6555995/#MOESM1",
        "access": "not inspected"
      }
    ],
    "review_scope": "Pivotal numerical inputs internally cross-checked; not every field independently re-extracted. No external review.",
    "registry_history": "Not verified"
  },
  {
    "family_id": "ENRADAS",
    "family_doi": "10.1186/s13075-019-1911-1",
    "url": "https://doi.org/10.1186/s13075-019-1911-1",
    "endpoint_id": "ENRADAS_le2",
    "arm": "Continuous/on-demand NSAID pooled",
    "population": "ENRADAS historical Primary Analysis Set",
    "week": 104,
    "threshold": "mSASSS change <=2",
    "construct": "composite spinal mSASSS nonprogression",
    "rate_percent": 72.5,
    "uncertainty": null,
    "uncertainty_reason": "not reported for this rate in inspected table/text",
    "denominator_n": 69,
    "estimate_type": "reported table percentage; logistic regression used for cohort comparison",
    "missing_data": "paired available films; no imputation described",
    "source_location": "Companion DOI10.1186/s13075-019-1911-1 Table2 primary set",
    "source_doi": "10.1186/s13075-019-1911-1",
    "source_access": "Full text inspected; see supplementary_access for narrower supplement coverage.",
    "supplementary_access": [
      {
        "url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC6555995/#MOESM1",
        "access": "not inspected"
      }
    ],
    "review_scope": "Pivotal numerical inputs internally cross-checked; not every field independently re-extracted. No external review.",
    "registry_history": "Not verified"
  },
  {
    "family_id": "PREVENT",
    "family_doi": "10.1186/s13075-023-03051-5",
    "url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC10186767/",
    "endpoint_id": "PREVENT_secukinumab_pooled_SDC",
    "arm": "secukinumab_pooled",
    "population": "PREVENT imaging-evaluable population",
    "week": 104,
    "threshold": "change in total mSASSS <= SDC (0.76)",
    "construct": "composite_mSASSS_nonprogression",
    "rate_percent": 97.5,
    "mean_change": null,
    "uncertainty": null,
    "uncertainty_reason": "not reported for this estimate in inspected location",
    "denominator_n": 280,
    "estimate_type": "reported_observed",
    "missing_data": "observed available radiographs; no outcome imputation",
    "source_location": "Results: Spinal radiographic progression, paragraph2",
    "numerator_n": 273,
    "source_access": "Full text inspected; see supplementary_access for narrower supplement coverage.",
    "supplementary_access": [
      {
        "url": "https://www.ebi.ac.uk/europepmc/webservices/rest/PMC10186767/supplementaryFiles",
        "access": "ZIP retrieved; relevant supplementary text inspected"
      }
    ],
    "review_scope": "Pivotal numerical inputs internally cross-checked; not every field independently re-extracted. No external review.",
    "registry_history": "Not verified"
  },
  {
    "family_id": "PREVENT",
    "family_doi": "10.1186/s13075-023-03051-5",
    "url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC10186767/",
    "endpoint_id": "PREVENT_secukinumab_pooled_GT2",
    "arm": "secukinumab_pooled",
    "population": "PREVENT imaging-evaluable population",
    "week": 104,
    "threshold": "increase in mSASSS >2",
    "construct": "composite_mSASSS_progression",
    "rate_percent": 1.1,
    "mean_change": null,
    "uncertainty": null,
    "uncertainty_reason": "not reported for this estimate in inspected location",
    "denominator_n": 280,
    "estimate_type": "reported_observed",
    "missing_data": "observed available radiographs; no outcome imputation",
    "source_location": "Results: Spinal radiographic progression, paragraph2",
    "numerator_n": 3,
    "source_access": "Full text inspected; see supplementary_access for narrower supplement coverage.",
    "supplementary_access": [
      {
        "url": "https://www.ebi.ac.uk/europepmc/webservices/rest/PMC10186767/supplementaryFiles",
        "access": "ZIP retrieved; relevant supplementary text inspected"
      }
    ],
    "review_scope": "Pivotal numerical inputs internally cross-checked; not every field independently re-extracted. No external review.",
    "registry_history": "Not verified"
  },
  {
    "family_id": "PREVENT",
    "family_doi": "10.1186/s13075-023-03051-5",
    "url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC10186767/",
    "endpoint_id": "PREVENT_secukinumab_pooled_mean",
    "arm": "secukinumab_pooled",
    "population": "PREVENT imaging-evaluable population",
    "week": 104,
    "threshold": "continuous change from baseline",
    "construct": "composite_mSASSS_change",
    "rate_percent": null,
    "mean_change": 0.04,
    "uncertainty": {
      "SD": 0.47
    },
    "denominator_n": 280,
    "estimate_type": "reported_observed",
    "missing_data": "observed available radiographs; no outcome imputation",
    "source_location": "Results: Spinal radiographic progression, paragraph1",
    "source_access": "Full text inspected; see supplementary_access for narrower supplement coverage.",
    "supplementary_access": [
      {
        "url": "https://www.ebi.ac.uk/europepmc/webservices/rest/PMC10186767/supplementaryFiles",
        "access": "ZIP retrieved; relevant supplementary text inspected"
      }
    ],
    "review_scope": "Pivotal numerical inputs internally cross-checked; not every field independently re-extracted. No external review.",
    "registry_history": "Not verified"
  },
  {
    "family_id": "PREVENT",
    "family_doi": "10.1186/s13075-023-03051-5",
    "url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC10186767/",
    "endpoint_id": "PREVENT_placebo_secukinumab_SDC",
    "arm": "placebo_secukinumab",
    "population": "PREVENT imaging-evaluable population",
    "week": 104,
    "threshold": "change in total mSASSS <= SDC (0.76)",
    "construct": "composite_mSASSS_nonprogression",
    "rate_percent": 97.1,
    "mean_change": null,
    "uncertainty": null,
    "uncertainty_reason": "not reported for this estimate in inspected location",
    "denominator_n": 136,
    "estimate_type": "reported_observed",
    "missing_data": "observed available radiographs; no outcome imputation",
    "source_location": "Results: Spinal radiographic progression, paragraph2",
    "numerator_n": 132,
    "source_access": "Full text inspected; see supplementary_access for narrower supplement coverage.",
    "supplementary_access": [
      {
        "url": "https://www.ebi.ac.uk/europepmc/webservices/rest/PMC10186767/supplementaryFiles",
        "access": "ZIP retrieved; relevant supplementary text inspected"
      }
    ],
    "review_scope": "Pivotal numerical inputs internally cross-checked; not every field independently re-extracted. No external review.",
    "registry_history": "Not verified"
  },
  {
    "family_id": "PREVENT",
    "family_doi": "10.1186/s13075-023-03051-5",
    "url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC10186767/",
    "endpoint_id": "PREVENT_placebo_secukinumab_GT2",
    "arm": "placebo_secukinumab",
    "population": "PREVENT imaging-evaluable population",
    "week": 104,
    "threshold": "increase in mSASSS >2",
    "construct": "composite_mSASSS_progression",
    "rate_percent": 0.7,
    "mean_change": null,
    "uncertainty": null,
    "uncertainty_reason": "not reported for this estimate in inspected location",
    "denominator_n": 136,
    "estimate_type": "reported_observed",
    "missing_data": "observed available radiographs; no outcome imputation",
    "source_location": "Results: Spinal radiographic progression, paragraph2",
    "numerator_n": 1,
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    "supplementary_access": [
      {
        "url": "https://www.ebi.ac.uk/europepmc/webservices/rest/PMC10186767/supplementaryFiles",
        "access": "ZIP retrieved; relevant supplementary text inspected"
      }
    ],
    "review_scope": "Pivotal numerical inputs internally cross-checked; not every field independently re-extracted. No external review.",
    "registry_history": "Not verified"
  },
  {
    "family_id": "PREVENT",
    "family_doi": "10.1186/s13075-023-03051-5",
    "url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC10186767/",
    "endpoint_id": "PREVENT_placebo_secukinumab_mean",
    "arm": "placebo_secukinumab",
    "population": "PREVENT imaging-evaluable population",
    "week": 104,
    "threshold": "continuous change from baseline",
    "construct": "composite_mSASSS_change",
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    "mean_change": 0.07,
    "uncertainty": {
      "SD": 0.36
    },
    "denominator_n": 136,
    "estimate_type": "reported_observed",
    "missing_data": "observed available radiographs; no outcome imputation",
    "source_location": "Results: Spinal radiographic progression, paragraph1",
    "source_access": "Full text inspected; see supplementary_access for narrower supplement coverage.",
    "supplementary_access": [
      {
        "url": "https://www.ebi.ac.uk/europepmc/webservices/rest/PMC10186767/supplementaryFiles",
        "access": "ZIP retrieved; relevant supplementary text inspected"
      }
    ],
    "review_scope": "Pivotal numerical inputs internally cross-checked; not every field independently re-extracted. No external review.",
    "registry_history": "Not verified"
  },
  {
    "family_id": "SELECT-AXIS-1",
    "family_doi": "10.1136/rmdopen-2022-002280",
    "url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC9335045/",
    "endpoint_id": "SELECT1_total_LT2",
    "arm": "pooled sequences",
    "population": "SELECT-AXIS-1 imaging-evaluable population",
    "week": 104,
    "threshold": "change in mSASSS <2",
    "construct": "composite_mSASSS_nonprogression",
    "rate_percent": 89.7,
    "mean_change": null,
    "uncertainty": null,
    "uncertainty_reason": "not reported for this estimate in inspected location",
    "denominator_n": 136,
    "estimate_type": "reported_observed",
    "missing_data": "observed available radiographs; no outcome imputation",
    "source_location": "Results: Imaging outcomes last sentence",
    "denominator_basis": "Table1 paired total cohort; not independently printed alongside rate",
    "source_access": "Full text inspected; see supplementary_access for narrower supplement coverage.",
    "supplementary_access": [
      {
        "url": "https://www.ebi.ac.uk/europepmc/webservices/rest/PMC9335045/supplementaryFiles",
        "access": "ZIP retrieved; relevant supplementary text inspected"
      }
    ],
    "review_scope": "Pivotal numerical inputs internally cross-checked; not every field independently re-extracted. No external review.",
    "registry_history": "Not verified"
  },
  {
    "family_id": "SELECT-AXIS-1",
    "family_doi": "10.1136/rmdopen-2022-002280",
    "url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC9335045/",
    "endpoint_id": "SELECT1_total_LE0",
    "arm": "pooled sequences",
    "population": "SELECT-AXIS-1 imaging-evaluable population",
    "week": 104,
    "threshold": "change in mSASSS <=0",
    "construct": "composite_mSASSS_nonprogression",
    "rate_percent": 76.5,
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    "uncertainty": null,
    "uncertainty_reason": "not reported for this estimate in inspected location",
    "denominator_n": 136,
    "estimate_type": "reported_observed",
    "missing_data": "observed available radiographs; no outcome imputation",
    "source_location": "Results: Imaging outcomes last sentence",
    "denominator_basis": "Table1 paired total cohort; not independently printed alongside rate",
    "source_access": "Full text inspected; see supplementary_access for narrower supplement coverage.",
    "supplementary_access": [
      {
        "url": "https://www.ebi.ac.uk/europepmc/webservices/rest/PMC9335045/supplementaryFiles",
        "access": "ZIP retrieved; relevant supplementary text inspected"
      }
    ],
    "review_scope": "Pivotal numerical inputs internally cross-checked; not every field independently re-extracted. No external review.",
    "registry_history": "Not verified"
  },
  {
    "family_id": "SELECT-AXIS-1",
    "family_doi": "10.1136/rmdopen-2022-002280",
    "url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC9335045/",
    "endpoint_id": "SELECT1_continuous_upadacitinib_mean",
    "arm": "continuous_upadacitinib",
    "population": "SELECT-AXIS-1 imaging-evaluable population",
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    "threshold": "continuous change from baseline",
    "construct": "composite_mSASSS_change",
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    "uncertainty": {
      "CI95": [
        0.1,
        1.1
      ],
      "method": "t-distribution"
    },
    "denominator_n": 69,
    "estimate_type": "reported_observed",
    "missing_data": "observed available radiographs; no outcome imputation",
    "source_location": "Table1 mean row",
    "source_access": "Full text inspected; see supplementary_access for narrower supplement coverage.",
    "supplementary_access": [
      {
        "url": "https://www.ebi.ac.uk/europepmc/webservices/rest/PMC9335045/supplementaryFiles",
        "access": "ZIP retrieved; relevant supplementary text inspected"
      }
    ],
    "review_scope": "Pivotal numerical inputs internally cross-checked; not every field independently re-extracted. No external review.",
    "registry_history": "Not verified"
  },
  {
    "family_id": "SELECT-AXIS-1",
    "family_doi": "10.1136/rmdopen-2022-002280",
    "url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC9335045/",
    "endpoint_id": "SELECT1_continuous_upadacitinib_LSmean",
    "arm": "continuous_upadacitinib",
    "population": "SELECT-AXIS-1 imaging-evaluable population",
    "week": 104,
    "threshold": "continuous change from baseline",
    "construct": "composite_mSASSS_change",
    "rate_percent": null,
    "mean_change": 0.6,
    "uncertainty": {
      "CI95": [
        0,
        1.2
      ],
      "method": "t-distribution"
    },
    "denominator_n": 69,
    "estimate_type": "ANCOVA_LSmean",
    "missing_data": "observed available radiographs; no outcome imputation",
    "source_location": "Table1 LS mean row",
    "source_access": "Full text inspected; see supplementary_access for narrower supplement coverage.",
    "supplementary_access": [
      {
        "url": "https://www.ebi.ac.uk/europepmc/webservices/rest/PMC9335045/supplementaryFiles",
        "access": "ZIP retrieved; relevant supplementary text inspected"
      }
    ],
    "review_scope": "Pivotal numerical inputs internally cross-checked; not every field independently re-extracted. No external review.",
    "registry_history": "Not verified"
  },
  {
    "family_id": "SELECT-AXIS-1",
    "family_doi": "10.1136/rmdopen-2022-002280",
    "url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC9335045/",
    "endpoint_id": "SELECT1_placebo_upadacitinib_mean",
    "arm": "placebo_upadacitinib",
    "population": "SELECT-AXIS-1 imaging-evaluable population",
    "week": 104,
    "threshold": "continuous change from baseline",
    "construct": "composite_mSASSS_change",
    "rate_percent": null,
    "mean_change": 0.8,
    "uncertainty": {
      "CI95": [
        0.2,
        1.4
      ],
      "method": "t-distribution"
    },
    "denominator_n": 67,
    "estimate_type": "reported_observed",
    "missing_data": "observed available radiographs; no outcome imputation",
    "source_location": "Table1 mean row",
    "source_access": "Full text inspected; see supplementary_access for narrower supplement coverage.",
    "supplementary_access": [
      {
        "url": "https://www.ebi.ac.uk/europepmc/webservices/rest/PMC9335045/supplementaryFiles",
        "access": "ZIP retrieved; relevant supplementary text inspected"
      }
    ],
    "review_scope": "Pivotal numerical inputs internally cross-checked; not every field independently re-extracted. No external review.",
    "registry_history": "Not verified"
  },
  {
    "family_id": "SELECT-AXIS-1",
    "family_doi": "10.1136/rmdopen-2022-002280",
    "url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC9335045/",
    "endpoint_id": "SELECT1_placebo_upadacitinib_LSmean",
    "arm": "placebo_upadacitinib",
    "population": "SELECT-AXIS-1 imaging-evaluable population",
    "week": 104,
    "threshold": "continuous change from baseline",
    "construct": "composite_mSASSS_change",
    "rate_percent": null,
    "mean_change": 0.9,
    "uncertainty": {
      "CI95": [
        0.3,
        1.5
      ],
      "method": "t-distribution"
    },
    "denominator_n": 67,
    "estimate_type": "ANCOVA_LSmean",
    "missing_data": "observed available radiographs; no outcome imputation",
    "source_location": "Table1 LS mean row",
    "source_access": "Full text inspected; see supplementary_access for narrower supplement coverage.",
    "supplementary_access": [
      {
        "url": "https://www.ebi.ac.uk/europepmc/webservices/rest/PMC9335045/supplementaryFiles",
        "access": "ZIP retrieved; relevant supplementary text inspected"
      }
    ],
    "review_scope": "Pivotal numerical inputs internally cross-checked; not every field independently re-extracted. No external review.",
    "registry_history": "Not verified"
  },
  {
    "family_id": "SELECT-AXIS-1",
    "family_doi": "10.1136/rmdopen-2022-002280",
    "url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC9335045/",
    "endpoint_id": "SELECT1_pooled sequences_mean",
    "arm": "pooled sequences",
    "population": "SELECT-AXIS-1 imaging-evaluable population",
    "week": 104,
    "threshold": "continuous change from baseline",
    "construct": "composite_mSASSS_change",
    "rate_percent": null,
    "mean_change": 0.7,
    "uncertainty": {
      "CI95": [
        0.3,
        1.1
      ],
      "method": "t-distribution"
    },
    "denominator_n": 136,
    "estimate_type": "reported_observed",
    "missing_data": "observed available radiographs; no outcome imputation",
    "source_location": "Table1 mean row",
    "source_access": "Full text inspected; see supplementary_access for narrower supplement coverage.",
    "supplementary_access": [
      {
        "url": "https://www.ebi.ac.uk/europepmc/webservices/rest/PMC9335045/supplementaryFiles",
        "access": "ZIP retrieved; relevant supplementary text inspected"
      }
    ],
    "review_scope": "Pivotal numerical inputs internally cross-checked; not every field independently re-extracted. No external review.",
    "registry_history": "Not verified"
  },
  {
    "family_id": "SELECT-AXIS-1",
    "family_doi": "10.1136/rmdopen-2022-002280",
    "url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC9335045/",
    "endpoint_id": "SELECT1_pooled sequences_LSmean",
    "arm": "pooled sequences",
    "population": "SELECT-AXIS-1 imaging-evaluable population",
    "week": 104,
    "threshold": "continuous change from baseline",
    "construct": "composite_mSASSS_change",
    "rate_percent": null,
    "mean_change": 0.7,
    "uncertainty": {
      "CI95": [
        0.3,
        1.2
      ],
      "method": "t-distribution"
    },
    "denominator_n": 136,
    "estimate_type": "ANCOVA_LSmean",
    "missing_data": "observed available radiographs; no outcome imputation",
    "source_location": "Table1 LS mean row",
    "source_access": "Full text inspected; see supplementary_access for narrower supplement coverage.",
    "supplementary_access": [
      {
        "url": "https://www.ebi.ac.uk/europepmc/webservices/rest/PMC9335045/supplementaryFiles",
        "access": "ZIP retrieved; relevant supplementary text inspected"
      }
    ],
    "review_scope": "Pivotal numerical inputs internally cross-checked; not every field independently re-extracted. No external review.",
    "registry_history": "Not verified"
  },
  {
    "family_id": "SELECT-AXIS-2",
    "family_doi": "10.1186/s13075-024-03412-8",
    "url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC11556075/",
    "endpoint_id": "SELECT2_continuous_upadacitinib_LT2",
    "arm": "continuous_upadacitinib",
    "population": "SELECT-AXIS-2 imaging-evaluable population",
    "week": 104,
    "threshold": "change in mSASSS <2",
    "construct": "composite_mSASSS_nonprogression",
    "rate_percent": 94.9,
    "mean_change": null,
    "uncertainty": null,
    "uncertainty_reason": "not reported for this estimate in inspected location",
    "denominator_n": 158,
    "estimate_type": "reported_observed",
    "missing_data": "observed available radiographs; no outcome imputation",
    "source_location": "Supplement TableS1 row no radiographic progression, footnotes c/b",
    "source_access": "Full text inspected; see supplementary_access for narrower supplement coverage.",
    "supplementary_access": [
      {
        "url": "https://www.ebi.ac.uk/europepmc/webservices/rest/PMC11556075/supplementaryFiles",
        "access": "ZIP retrieved; relevant supplementary text inspected"
      }
    ],
    "review_scope": "Pivotal numerical inputs internally cross-checked; not every field independently re-extracted. No external review.",
    "registry_history": "Not verified"
  },
  {
    "family_id": "SELECT-AXIS-2",
    "family_doi": "10.1186/s13075-024-03412-8",
    "url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC11556075/",
    "endpoint_id": "SELECT2_continuous_upadacitinib_LSmean",
    "arm": "continuous_upadacitinib",
    "population": "SELECT-AXIS-2 imaging-evaluable population",
    "week": 104,
    "threshold": "continuous change from baseline",
    "construct": "composite_mSASSS_change",
    "rate_percent": null,
    "mean_change": 0.12,
    "uncertainty": null,
    "uncertainty_reason": "not reported for this estimate in inspected location",
    "denominator_n": 158,
    "estimate_type": "AO_ANCOVA_LSmean",
    "missing_data": "observed available radiographs; no outcome imputation",
    "source_location": "Main Figure4 graphic; text rounds to0.1/0.2",
    "source_access": "Full text inspected; see supplementary_access for narrower supplement coverage.",
    "supplementary_access": [
      {
        "url": "https://www.ebi.ac.uk/europepmc/webservices/rest/PMC11556075/supplementaryFiles",
        "access": "ZIP retrieved; relevant supplementary text inspected"
      }
    ],
    "review_scope": "Pivotal numerical inputs internally cross-checked; not every field independently re-extracted. No external review.",
    "registry_history": "Not verified"
  },
  {
    "family_id": "SELECT-AXIS-2",
    "family_doi": "10.1186/s13075-024-03412-8",
    "url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC11556075/",
    "endpoint_id": "SELECT2_placebo_upadacitinib_LT2",
    "arm": "placebo_upadacitinib",
    "population": "SELECT-AXIS-2 imaging-evaluable population",
    "week": 104,
    "threshold": "change in mSASSS <2",
    "construct": "composite_mSASSS_nonprogression",
    "rate_percent": 93.8,
    "mean_change": null,
    "uncertainty": null,
    "uncertainty_reason": "not reported for this estimate in inspected location",
    "denominator_n": 162,
    "estimate_type": "reported_observed",
    "missing_data": "observed available radiographs; no outcome imputation",
    "source_location": "Supplement TableS1 row no radiographic progression, footnotes c/b",
    "source_access": "Full text inspected; see supplementary_access for narrower supplement coverage.",
    "supplementary_access": [
      {
        "url": "https://www.ebi.ac.uk/europepmc/webservices/rest/PMC11556075/supplementaryFiles",
        "access": "ZIP retrieved; relevant supplementary text inspected"
      }
    ],
    "review_scope": "Pivotal numerical inputs internally cross-checked; not every field independently re-extracted. No external review.",
    "registry_history": "Not verified"
  },
  {
    "family_id": "SELECT-AXIS-2",
    "family_doi": "10.1186/s13075-024-03412-8",
    "url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC11556075/",
    "endpoint_id": "SELECT2_placebo_upadacitinib_LSmean",
    "arm": "placebo_upadacitinib",
    "population": "SELECT-AXIS-2 imaging-evaluable population",
    "week": 104,
    "threshold": "continuous change from baseline",
    "construct": "composite_mSASSS_change",
    "rate_percent": null,
    "mean_change": 0.2,
    "uncertainty": null,
    "uncertainty_reason": "not reported for this estimate in inspected location",
    "denominator_n": 162,
    "estimate_type": "AO_ANCOVA_LSmean",
    "missing_data": "observed available radiographs; no outcome imputation",
    "source_location": "Main Figure4 graphic; text rounds to0.1/0.2",
    "source_access": "Full text inspected; see supplementary_access for narrower supplement coverage.",
    "supplementary_access": [
      {
        "url": "https://www.ebi.ac.uk/europepmc/webservices/rest/PMC11556075/supplementaryFiles",
        "access": "ZIP retrieved; relevant supplementary text inspected"
      }
    ],
    "review_scope": "Pivotal numerical inputs internally cross-checked; not every field independently re-extracted. No external review.",
    "registry_history": "Not verified"
  },
  {
    "family_id": "CONSUL",
    "family_doi": "10.1136/ard-2023-224699",
    "url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC11041582/",
    "endpoint_id": "CONSUL_GOL_CEL_mean",
    "arm": "GOL_CEL",
    "population": "Adults with r-axSpA, high progression risk; randomized after sufficient response to12-week golimumab run-in.",
    "week": 108,
    "threshold": "continuous change",
    "construct": "composite_mSASSS",
    "mean_change": 1.1,
    "rate_percent": null,
    "uncertainty": {
      "type": "95%CI",
      "lower": 0.4,
      "upper": 1.8
    },
    "denominator_n": 54,
    "estimate_type": "ITT multiple-imputation mean",
    "missing_data": "<=8missing corners: other-timepoint score or0if both missing; otherwise20multiple imputations, separately by arm and reader; imputation uses baseline score,time lag,CRP.",
    "source_location": "Main analysis; Figure3A; Methods Statistical analysis",
    "source_access": "Full text inspected; see supplementary_access for narrower supplement coverage.",
    "supplementary_access": [
      {
        "url": "https://www.ebi.ac.uk/europepmc/webservices/rest/PMC11041582/supplementaryFiles",
        "access": "retrieval_timeout"
      }
    ],
    "review_scope": "Pivotal numerical inputs internally cross-checked; not every field independently re-extracted. No external review.",
    "registry_history": "Not verified"
  },
  {
    "family_id": "CONSUL",
    "family_doi": "10.1136/ard-2023-224699",
    "url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC11041582/",
    "endpoint_id": "CONSUL_GOL_mean",
    "arm": "GOL",
    "population": "Adults with r-axSpA, high progression risk; randomized after sufficient response to12-week golimumab run-in.",
    "week": 108,
    "threshold": "continuous change",
    "construct": "composite_mSASSS",
    "mean_change": 1.7,
    "rate_percent": null,
    "uncertainty": {
      "type": "95%CI",
      "lower": 0.8,
      "upper": 2.6
    },
    "denominator_n": 55,
    "estimate_type": "ITT multiple-imputation mean",
    "missing_data": "<=8missing corners: other-timepoint score or0if both missing; otherwise20multiple imputations, separately by arm and reader; imputation uses baseline score,time lag,CRP.",
    "source_location": "Main analysis; Figure3A; Methods Statistical analysis",
    "source_access": "Full text inspected; see supplementary_access for narrower supplement coverage.",
    "supplementary_access": [
      {
        "url": "https://www.ebi.ac.uk/europepmc/webservices/rest/PMC11041582/supplementaryFiles",
        "access": "retrieval_timeout"
      }
    ],
    "review_scope": "Pivotal numerical inputs internally cross-checked; not every field independently re-extracted. No external review.",
    "registry_history": "Not verified"
  },
  {
    "family_id": "ASSERT",
    "family_doi": "10.1136/rmdopen-2020-001391",
    "url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC7856152/",
    "endpoint_id": "ASSERT_both",
    "arm": "Pooled parent treatment histories",
    "population": "Trial-derived r-axSpA subset with baseline DXA and baseline/two-year spinal radiographs; analysis restricted to L1–L4.",
    "week": 102,
    "threshold": "Corner grade0/1 to2/3; both readers agree",
    "construct": "new_syndesmophyte_patient_indicator",
    "rate_percent": 5,
    "numerator_n": 9,
    "mean_change": null,
    "uncertainty": null,
    "uncertainty_reason": "Not reported for descriptive patient rate",
    "denominator_n": 165,
    "estimate_type": "Observed rounded patient percentage",
    "missing_data": "Included baseline DXA and paired radiographs; excludes vertebrae with fracture or baseline syndesmophytes; no whole-outcome imputation described.",
    "source_location": "Methods Outcome definition; Results Incidence of new syndesmophyte formation",
    "source_access": "Full text inspected; see supplementary_access for narrower supplement coverage.",
    "supplementary_access": [],
    "review_scope": "Pivotal numerical inputs internally cross-checked; not every field independently re-extracted. No external review.",
    "registry_history": "Not verified"
  },
  {
    "family_id": "ASSERT",
    "family_doi": "10.1136/rmdopen-2020-001391",
    "url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC7856152/",
    "endpoint_id": "ASSERT_either",
    "arm": "Pooled parent treatment histories",
    "population": "Trial-derived r-axSpA subset with baseline DXA and baseline/two-year spinal radiographs; analysis restricted to L1–L4.",
    "week": 102,
    "threshold": "Corner grade0/1 to2/3; at least one reader",
    "construct": "new_syndesmophyte_patient_indicator",
    "rate_percent": 18,
    "numerator_n": 30,
    "mean_change": null,
    "uncertainty": null,
    "uncertainty_reason": "Not reported for descriptive patient rate",
    "denominator_n": 165,
    "estimate_type": "Observed rounded patient percentage",
    "missing_data": "Included baseline DXA and paired radiographs; excludes vertebrae with fracture or baseline syndesmophytes; no whole-outcome imputation described.",
    "source_location": "Methods Outcome definition; Results Incidence of new syndesmophyte formation",
    "source_access": "Full text inspected; see supplementary_access for narrower supplement coverage.",
    "supplementary_access": [],
    "review_scope": "Pivotal numerical inputs internally cross-checked; not every field independently re-extracted. No external review.",
    "registry_history": "Not verified"
  }
]